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Vol. 53. Issue 200.
Pages 155-162 (October 2018)
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Vol. 53. Issue 200.
Pages 155-162 (October 2018)
Miocinas y regulación metabólica, una revisión sistemática
A systematic review of “myokines and metabolic regulation”
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Henry H. León-Arizaa, María P. Mendoza-Navarretea, María I. Maldonado-Arangoa, Daniel A. Botero-Rosasa
a Departamento de Morfofisiología, Facultad de Medicina, Universidad de la Sabana, Chía, Colombia.
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Malos hábitos como el sedentarismo, la obesidad o la sobrealimentación se relacionan con la evolución de estados pro-inflamatorios crónicos, principal factor de riesgo para el desarrollo de enfermedades crónicas no transmisibles (ECNT). Sin embargo, modificar únicamente el peso corporal no reduce el riesgo; es necesario también aumentar la masa muscular, dando a entender que existe una relación benéfica asociada a este tejido que no está totalmente dilucidada. Durante los últimos años las explicaciones celulares más interesantes se han centrado en la producción de citocinas musculares denominadas miocinas, dentro de las que destacan la interleucina 6, el factor inhibidor de la leucemia, entre otras recientemente estudiadas como la mionectina y la musclina. Debido a los múltiples avances, se realiza una revisión que pretende presentar los hallazgos más recientes y representativos acerca de las miocinas, corregir conceptos y demostrar su aplicabilidad en la prescripción del ejercicio físico para la salud.

Palabras clave:
Miocinas; Regulación metabólica; Ejercicio

Bad habits such as sedentary lifestyle, obesity or overfeeding, are related to the production of chronic pro-inflammatory states, the main risk factor for the development of chronic noncommunicable diseases (CNCD). However, modifying only the body weight does not reduce the risk, it is necessary to increase muscle mass, this implies there is a beneficial relationship associated with the muscle tissue that is not fully elucidated. During the last years, the most interesting cellular explanations have focused on the production of muscle cytokines called myokines, among which stand out interleukin 6, the inhibitory factor of leukemia, with others recently studied such as mionectine and muscline. Due to the multiple advances, this paper intends to present the most recent and representative findings about myokines, correct concepts and demonstrate their applicability in the prescription of physical exercise for health.

Keywords:
Myokines; Metabolic regulation; Exercise

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